The North Carolina
Integrative Medical Society

PO Box 6472
Raleigh, NC 27628
919-833-5092
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The Nutritional and Biological Integrative Medical Treatment of Diseases

Purposes of the Activity
According to recent research nearly one in three Americans seek use some kind of complementary therapy.  Health care providers need a good basic understanding of the science of nutrition so that they can keep up with the burgeoning literature to which they (and their patients) are exposed. The latest scientific findings on Integrative Medicine approaches and nutrition are needed to further their knowledge.  Nutrition can serve as a foundation for preventive medicine and the new health care model.  Patients should be provided information about treatments to make informed decisions about the non-traditional therapies. 

Goals

  • To review recent findings about medical conditions and aspects of optimal health and Integrative Medicine interventions.
  • To highlight the laws affecting health professionals.
  • To recognize the appropriate consent for Integrative Medical treatments, malpractice and fees.
  • To review types of medical malpractice insurance.

Objectives
At the conclusion of this course, participants should be better able to:

  • Evaluate and implement best practices in the treatment and prevention of common medical conditions and chronic illnesses using evidence-based Integrative Medicine.
  • Integrate patient-care treatment including Integrative Medicine into their practices or refer to specialists as necessary.
  • Implement appropriate patient consent procedures in their practices.

Target Audience
The conference is designed for family practice, internal medicine, primary care, integrative medicine physicians; nurses; pharmacists; dentists; dietitians; and other health professionals.

Faculty/Planner/Staff Disclosure
Disclosure of faculty and commercial relationships will be made known at the activity. Speakers are required to openly disclose any limitations of data and/or any discussion of any off-label, experimental, or investigational uses of drugs or devices in their presentations.  

Disclaimer
The information provided at this CME activity is for continuing medical education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

Educational Grant Disclosure 
Apex Energetics, Xymogen, Genova Diagnostic Lab, Fairway Physicians Insurance Company, Immuno Laboratories

Credit Designation

This CME activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education thru the Joint Sponsorship of the Institute for Medical Studies (IMS) and North Carolina Integrative Medical Society.  IMS is accredited by the ACCME to provide continuing medical education for physicians. 

The Institute for Medical Studies designates this educational activity for a maximum of 10 AMA PRA Category 1 Credits™.  Physicians should only claim credit commensurate with the extent of their participation in the activity. 

Nurses may claim credit for activities approved for AMA PRA Category 1 Credits ™ in most states, for up to 50% of the nursing requirement for recertification. This activity is designated for up to 10 AMA PRA Category1 Credits ™
 
Nurse Practitioners: The American Academy of Nurse Practitioners (AANP) accepts AMA PRA Category 1 Credit(s)TM from organizations accredited by the ACCME. IMS is accredited to provide continuing medical education for physicians and will provide nurse practitioners who successfully complete each activity with a certificate of participation indicating that the activity was designated for AMA PRA Category 1 Credit(s)TM. 

The American Academy of Physician Assistants (AAPA) accepts AMA PRA Category 1 Credits™ from organizations accredited by the ACCME. The provider of this program, the Institute for Medical Studies, is accredited by the ACCME and designates this educational activity for a maximum of 10 AMA PRA Category 1 Credit(s)TM. Physician assistants should only claim credit commensurate with the extent of their participation in the activity. 

American College of Medical Practice Executives (ACMPE) accepts AMA PRA Category 1 Credit(s)TM from organizations accredited by ACCME.  Administrators should only claim credit commensurate with the extent of their participation in the activity.

Nutritional Evaluation: The Link Between Depression & Fatigue Issues And Nutritional Biochemistry
 - Patrick Hanaway, MD

Disclosure Statement
No Conflict of Interest

Purpose of Activity
Vitamin and nutritional supplementation is a critical factor in correcting physical and mental illness, as well as an effective means for promoting health and maintaining wellness. Over the past 30 years there has been an exponential increase in the utilization of nutritional supplements, though the development of empiric tools to quantitative the need for these supplemental nutrients – in the form of vitamins and minerals – has not been well characterized. Through the deepening understanding of nutritional biochemistry and biochemical individuality, tools are now available, utilizing in silica processing to determine the functional effect of nutritional deficiencies in: B-vitamins, anti-oxidants, amino acids, nutritional co-factors, essential minerals, and essential fatty acids. The proper application of essential minerals, B-vitamins, anti-oxidants, amino acids, and essential fats promotes the body’s ability to heal from illness and disease. Now practitioners will have tools in their toolbox to personalize supplement recommendations. This is exactly what patients have been asking for from their physicians. 

Goals:
• To review the functional need for nutrients and diagnostic testing to individualize supplement therapies.
• To recognize the clinical benefit of personalized vitamin therapies.
• To highlight individualized nutritional needs based upon genomic polymorphisms and genetic predisposition. 

Learning Objectives:
At the end of this presentation, the participants should be able to:
• To apply functional nutritional testing to issues of depression, addiction, fatigue, and aging.
• Review different methodologies for assessing functional nutritional needs.
• To recognize the inter-relationship of digestion, absorption, and amino acid

Integrating Advanced Vascular Risk Factors -  James Biddle MD 

Disclosure Statement
No Conflict of Interest

Purpose of Activity
Atherosclerotic Vascular Disease is the leading cause of death in the industrialized world.  Physicians need to know the pathophysiology of atherosclerosis, the classic vascular risk factors, and novel and emerging vascular risk factors.  These include inflammation, poor dietary choices, sleep apnea, testosterone deficiency, homocysteine, Lp(a), iron overload, and elevated burdens of lead, cadmium, mercury, and arsenic.  In addition, physicians should understand non-invasive methods to evaluate the severity and progression of ASCVD. 

Goals
• Review the pathophysiology of vascular disease propagation.
• Review classic risk factors for vascular disease.
• Introduce novel and emerging risk factors for vascular disease.
• Educate physicians about non-invasive techniques to monitor the progression of vascular disease.

Objectives
• At the end of the session the participant will be able to…
• Learn the pathophysiology of ASCVD.
• Identify classic and novel risk factors for vascular disease.
• Review techniques for assessing the severity of ASCVD.

The Bent Creek Germplasm Repository, A Research and Conservation Tool for Natural Product Research
 – Joe-Ann H. McCoy, PhD 

Disclosure Statement
No Conflict of Interest

Purpose of Activity
The establishment of robust germplasm collections is an important tool for the development of natural product reserach through the long-term conservation of valuable  selections.  Germplasm is stored in the form of seeds, living plants and DNA.  As natural product research becomes more sophisticated, there is increased demand from peer research agencies to require plant materials of known genetic origins in order to produce high quality, reproducibleresearch results, however, access to a recognized source of known-origin material for many experimental studies is not currently available.  The Bent Creek Germplasm Repository (BCGR) at the NC Arboretum, located in Asheville focuses primarily as a supplier and long-term storage facility for natural product germplasm associated with all project collaborations.

A germplasm collaboration ensure that all research materials used for proposed projects have associated  1) authenticated botanical vouchers in triplicate scanned at high resolution and stored under controlled conditions in the NCA  Herbarium  2) plant material and / or extract samples stored under controlled conditions and available by researcher upon request , 3) DNA samples collected on FTA cards and stored under controlled conditions available for analysis, and 4) seed samples representing appropriate allelic diversity for each accession and stored under vacuum in controlled long-term storage facilities.  All germplasm collection, drying, and storage methods utilized follow specific guidelines established by the USDA NPGS (National Plant Germplasm System), PGOC (Plant Germplasm Operations Committee) and specific guidelines for preserving plant genetic diversity.  In addition all collection permits are procured in advance in accordance to state and federal regulations.  Collection, drying, harvesting, and seed and sample storage follow the AHPA-AHP Good Agricultural and Collection Practices methods (2006) and that of Europe (2006) and WHO (2003).  In addition, the BCGR edits all associated publications to ensure that germplasm sources are correctly identified and taxonomically represented accurately. A collaborative germplasm focus enables researchers and stakeholders to have full access to identical germplasm sources and helps insure that associated future studies can potentially be replicated with similar results.

Goals
• To introduce the concept and importance of germplasm repositories for natural product research for the long-term storage of research lines, extracts, and DNA samples
• To give examples of numerous state and federal research projects resulting from robust germplasm collections
• To stress the importance of utilizing source materials of known origin for natural product research in order to replicate current studies in the future 

Learning Objectives
At the end of this presentation, the participants should be able to understand the concept of source material variation and importance of germplasm repositories for natural product research.

Anticipating Potential Medico-Legal Risk Affecting the Practice Of Medicine
 – Jeffrey Segal, MD, JD, FACS /Jean Boyles, Licensed to Practice in NC since 1973

Disclosure Statement
Jeffrey Segal, MD is founder and CEO of Medical Justice.
Jean Boyles – No conflict of interest. 

Purpose of Activity
It is critical that health professionals understand the Medioco-Legal risks so that they prepare consent forms and establish office procedures that reduce risks.  Patients need to have clear information about the treatments they receive and the associated fees. Health professionals must be able to use websites and the internet productively. 

Goals
• Address how online comments can build and destroy practitioner’s reputation
• Focus on steps that can and cannot be taken to address online assaults against practitioner’s reputation
• Define concrete ways to avoid frivolous medical malpractice lawsuits
• Define ways to introduce and use innovative medical techniques in line with state licensing board expectations
• To review appropriate patient consent for non-conventional therapies, fees, and malpractice.

Objectives
At the end of this presentation, the participants should be able:
• To implement appropriate patient consent procedures in their practices.
• To recognize malpractice financial options.
• Participants should be able to preemptively address medico-legal threat initiated by online defamatory attacks.
• Participants should be able to thwart meritless professional liability lawsuits
• Participants should be able to preemptively address concerns by state licensing boards.

An Integrative Approach to Effective Clinical Management of Osteopenia/Osteoporosis
 - Dr. Cheryl Burdette, ND

Disclosure Statement
No Conflict of Interest 

Purpose of Activity
Educate practitioners in the field of bone health and re-growth and the strategies therein.  Instruct participants about the use of FDA approved testing strategies that detect early onset of disease resulting in early intervention and innovative modes of treatment through improved documented reduced risk for fractures and the monitoring of improvements of these values. 

Goals
• To review current education on the debilitating disease of Osteoporosis.
• Recognize the clinical benefit of personalized vitamin therapies
• To highlight individualized nutritional needs based upon genomic polymorphisms and genetic predisposition. 

Objectives
At the end of this presentation, the participants should be able to:
• To apply functional nutritional testing to issues of depression, addiction, fatigue, and aging.
• Review different methodologies for assessing functional nutritional needs.
• To recognize the inter-relationship of digestion, absorption, and amino acid

An Integrative Medical Approach to Lyme Disease and other Tick-Borne Illnesses
 - John C. Pittman, MD bsp;

Disclosure Statement
No conflicts of interest.

Purpose of Activity
Lyme Disease may be fully regarded as a symptom complex of Borreliosis and multiple co-infections with associated musculoskeletal and neurologic inflammation as well as immune dysfunction.   The Integrative Medical approach to Lyme disease focuses on the appropriate use of antibiotics to treat Borrelia and co-infections, as well as on therapies to address immune system dysfunctions, inflammatory problems, hormonal abnormalities and neurological issues related to the pathogenesis of these infections.  In addition, this approach addresses the co-morbidities of neurotoxic substances (both chemicals and metals), non-tick borne infections, intestinal inflammation, nutritional deficiencies, food allergies, and autoimmunity.\

Goals
• To review the causes of Lyme Disease and Tick Borne Illnesses, including Borrelia species, co-infections and the probable predisposing role of immune system impairment.
• To review the key issues in diagnosis, staging, and laboratory testing for Lyme disease.
• To identify the secondary disturbances found in many cases of tick-borne illnesses.
• To recognize the clinical benefit of treating the infections and secondary disturbances using a combination of conventional and CAM modalities. 
• To highlight antibiotic strategies and address the optimal use of antibiotics in the context of Integrative Medicine.
• To delineate the therapeutic rationale for using specific supplements, hormonal support, immune modulating therapies, hyperbaric oxygen therapy, and other CAM strategies for the treatment and management of Lyme Disease.  

Objectives
At the end of this presentation, the participants should be able to:
• Apply functional medicine testing to assess the underlying biological needs of patients diagnosed with Lyme Disease and Tick Borne Illnesses. 
• Review different methodologies for the Integrative Medical management of Lyme arthritis, myalgia syndromes, chronic fatigue, and other Lyme-associated problems.
• Recognize the CAM strategies that are most likely to benefit Lyme disease patients.

Mechanisms Of Neurodegeneration: Nutritional Approaches to Prevention and Treatment
 – David Clark, DC, DACNB

Disclosure Statement
No Conflict of Interest 

Purpose of Activity
Neurodegeneration affects many physiological systems, including endocrine, immune, gastrointestinal and hepatic. However, clinically, neurodegeneration is often missed as the root cause of non-neurological symptoms. Recent research has given us a better understanding of this connection as well as some of the mechanisms behind neurodegeneration, including microglia activation, the energy-linked excitotoxic model, hypoxia, as well as gluten sensitivity. The literature also reveals many natural compounds found to be effective at preventing and/or dampening these specific mechanisms.  

Goals
• To review the some of the extra-neurological effects of neurodegeneration.
• To review some of the mechanisms of neurodegeneration, specifically microglia activation, the energy-linked excitotoxic model, and hypoxia.
• To review the literature for natural compounds shown helpful in the prevention and/or treatment of the mechanisms of neurodegeneration.
• To review the literature for connections between neurodegeneration and gluten intolerance.
 
Objectives
At the end of this presentation, the participants should be able to:
• Recognize the relationship between certain extra-neurological symptoms and neurodegeneration. 
• Have an understanding of some of the mechanisms of neurodegeneration.
• Identify natural compounds for clinical use in the prevention and treatment of the mechanisms of neurodegeneration.
• Recognize the connection between neurodegeneration and gluten intolerance.

The Role of Hidden Infections in Chronic Fatigue
 - Joanne Pizzino, MD, MPH, FACOEM

Disclosure Statement
No conflicts of interest 

Purpose of Activity
Provide practitioners with a comprehensive understanding of Chronic Fatigue/Immune Deficiency Syndrome (CFIDS) and its relationship to underlying infections.   Describe the clinical disease presentation and the detection of infections. Through deepening understanding of intervention and innovative modes of treatment, patients will have improved functioning. 

Goals
• To review definitions and presentations of Chronic Fatigue/Immune Deficiency Syndrome (CFIDS)
• To present a comprehensive multi-system model of the pathogenesis of CFIDS
• To review literature demonstrating a role for the immune system and infection in CFIDS
• To present Integrative Medicine modalities to improve functioning in CFIDS patients

Objectives
At the end of this presentation, the participants should be able to:
• Recognize the relationship between Chronic Fatigue/Immune Deficiency Syndrome (CFIDS) and inflection.
• Have an understanding of comprehensive multi-system model of the pathogenesis of CFIDS.
• Recognize the role of support for the immune system in the treatment of CFIDS
• Understand the Integrative Medicine modalities to improve functioning in CFIDS patients

The Link between Foods and your Patient’s Chronic Conditions
- Amir Koohestani DO 

Purpose of Activity
Over the course of a lifetime, an average American, consumes an estimated 25 tons of food. Foodstuff must traverse the GI tract and comes in contact with approximately 400 square meters of GI mucosal membrane, the largest interface between our body, and the outside world. This obviously provides ample opportunity for both toxic and nontoxic interactions between food and the human body. Nontoxic adverse food reactions are classified based on their pathogenic mechanisms into food allergy and food intolerance.  This presentation examines the pathophysiology of adverse food reactions and their role in initiation and propagation of chronic disease states while specifically elaborating on evidence-based integrative medical solutions for evaluation and treatment of individuals with food allergies. 

Goals

  • To review the current classification of adverse food reactions
  • To review the pathophysiology of food allergy and intolerance and the link to chronic disease
  • To introduce an evidence-based integrative medical model for evaluation and treatment of a patient with food allergies

Objectives

  • At the end of this presentation, the participants should be able to:
  • Successfully differentiate between nontoxic and toxic food reactions
  • Recognize the distinct processes involved in food allergy versus intolerance
  • Understand the pathophysiology of food allergies in chronic disease
  • Have a working knowledge of testing for immediate versus delayed food allergies
  • Implement an integrative medical plan in caring for patients with food allergies